MyBioSource.com's PRKAR2B Antibody (Center) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The PRKAR2B Antibody (Center) was generated using PKARIIbeta, and PRKAR2B as the antigen and it reacts with Human, Mouse, and Rat.
Description
cAMP is a signaling molecule important for a variety of
cellular functions. cAMP exerts its effects by activating the
cAMP-dependent protein kinase, which transduces the signal through
phosphorylation of different target proteins. The inactive kinase
holoenzyme is a tetramer composed of two regulatory and two
catalytic subunits. cAMP causes the dissociation of the inactive
holoenzyme into a dimer of regulatory subunits bound to four cAMP
and two free monomeric catalytic subunits. Four different
regulatory subunits and three catalytic subunits have been
identified in humans. The protein encoded by this gene is one of
the regulatory subunits. This subunit can be phosphorylated by the
activated catalytic subunit. This subunit has been shown to
interact with and suppress the transcriptional activity of the cAMP
responsive element binding protein 1 (CREB1) in activated T cells.
Knockout studies in mice suggest that this subunit may play an
important role in regulating energy balance and adiposity. The
studies also suggest that this subunit may mediate the gene
induction and cataleptic behavior induced by haloperidol. [provided
by RefSeq]